Plenary paper Expansion of peripheral naturally occurring T regulatory cells by Fms-like tyrosine kinase 3 ligand treatment

نویسندگان

  • Lee Kim Swee
  • Nabil Bosco
  • Bernard Malissen
  • Rhodri Ceredig
  • Antonius Rolink
چکیده

1Departement Biomedizin Basel, Division of Molecular Immunology, University of Basel, Basel, Switzerland; 2Centre d’Immunologie de Marseille-Luminy, Université de la Méditerrannée, Inserm Unité 631, Centre National de la Recherche Scientifique (CNRS) Unité Mixte de Recherche (UMR) 6102, Marseille, France; and 3Inserm Unité 645, Université Franche-Comté, Etablissement Français du Sang, Bourgogne Franche-Comté, Institut Fédératif de Recherche 133, Besançon, France

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Expansion of peripheral naturally occurring T regulatory cells by Fms-like tyrosine kinase 3 ligand treatment.

Fms-like tyrosine kinase 3 ligand (FLT3L) plays a major role in dendritic cell (DC) biology. Deficiency of FLT3L causes a dramatic decrease in DC numbers, whereas increasing its availability (by repetitive injections for 7-10 days) leads to a 10-fold increase in DC numbers. In this study, we show that FLT3L treatment indirectly leads to an expansion of peripheral naturally occurring T regulator...

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تاریخ انتشار 2009